挖出来一片关于酒精消杀肠病毒的古董文献(全文找到了)
Journal of Hospital Infection
Volume 1, Issue 4, December 1980, Pages 321-325
Original article
The action of alcohols on rotavirus, astrovirus and enterovirus
J. B. Kurtz, T. W. Lee and A. J. Parsons
Virology Laboratory and Public Health Laboratory, John Radcliffe Hospital, Oxford OX 3 9DU, U.K.
Available online 18 May 2004.
This article is not included in your organization's subscription. However, you may be able to access this article under your organization's agreement with Elsevier.
Abstract
The virucidal effects of a series of five alcohols on rotavirus, astrovirus and echovirus 11 were studied. The reaction time between the alcohol and virus was one minute, a time for which a hand disinfectant might be applied. The efficacy of the alcohols rose with the concentration used. Forty per cent concentrations of the higher alcohols (propan-1-ol, propan-2-ol and butan-2-ol) caused at least a 104-fold drop in rotavirus titre. Methanol and ethanol were not quite as effective against rotavirus, but were the only alcohols of those tested that reduced the titres of the more resistant astrovirus and echovirus 11, and then only when used at high concentrations. Preparations incorporating 90 per cent ethanol are recommended as hand disinfectants with a broad virucidal activity.
整个pubmed上只有这一篇1980年的文章写过，但是文章太老，没有全文，而且也只是针对肠病毒的一个种埃可病毒11型，并没有提到EV71。不过都同属于一个种，应该有参考意义。大家再跟贴。明天再翻翻原版书，看看埃可病毒和EV71病毒结构是否相似，如果相似，貌似司徒教授说的有几分道理。
[ 本帖最后由 David 于 2008-5-28 11:38 编辑 ]
Volume 1, Issue 4, December 1980, Pages 321-325
Original article
The action of alcohols on rotavirus, astrovirus and enterovirus
J. B. Kurtz, T. W. Lee and A. J. Parsons
Virology Laboratory and Public Health Laboratory, John Radcliffe Hospital, Oxford OX 3 9DU, U.K.
Available online 18 May 2004.
This article is not included in your organization's subscription. However, you may be able to access this article under your organization's agreement with Elsevier.
Abstract
The virucidal effects of a series of five alcohols on rotavirus, astrovirus and echovirus 11 were studied. The reaction time between the alcohol and virus was one minute, a time for which a hand disinfectant might be applied. The efficacy of the alcohols rose with the concentration used. Forty per cent concentrations of the higher alcohols (propan-1-ol, propan-2-ol and butan-2-ol) caused at least a 104-fold drop in rotavirus titre. Methanol and ethanol were not quite as effective against rotavirus, but were the only alcohols of those tested that reduced the titres of the more resistant astrovirus and echovirus 11, and then only when used at high concentrations. Preparations incorporating 90 per cent ethanol are recommended as hand disinfectants with a broad virucidal activity.
整个pubmed上只有这一篇1980年的文章写过，但是文章太老，没有全文，而且也只是针对肠病毒的一个种埃可病毒11型，并没有提到EV71。不过都同属于一个种，应该有参考意义。大家再跟贴。明天再翻翻原版书，看看埃可病毒和EV71病毒结构是否相似，如果相似，貌似司徒教授说的有几分道理。
[ 本帖最后由 David 于 2008-5-28 11:38 编辑 ]
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鹊翔阿亮&&
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手揉搓液中一定浓度的酒精，人体实验证实对一些无膜的病毒有效（表Ⅰ.9.3），例如人体实验中使用指腹模式证实，70％丙醇和乙醇对轮状病毒的有效性高于抗菌皂液和非抗菌皂液（178，225）。更新的一项研究使用同样的模式来评价含60％酒精商品，发现降低三种感染性的病毒（轮状病毒、腺病毒和鼻病毒）3－4log10（226）。其它无膜的病毒如甲肝病毒和肠道病毒（如脊髓灰质炎病毒）则要求70％－80％浓度的酒精（227，228）。
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