新英格兰医学杂志关于1998年台湾肠病毒EV71暴发感染情况的调查汇总（已翻译摘要）

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BACKGROUND: Enteroviruses can cause outbreaks of hand-foot-and-mouth disease (characterized by vesicular lesions on the hands, feet, and oral mucosa) or herpangina, usually without life-threatening manifestations.(背景：肠病毒能够引起手足口病的暴发，典型症状是手、足、口腔粘膜囊泡状病变，或者疱疹性咽峡炎，通常不会危及生命。) In 1998 an epidemic of enterovirus 71 infection caused hand-foot-and-mouth disease and herpangina in thousands of people in Taiwan, some of whom died.（1998年，台湾发生了一次大范围的肠病毒EV71暴发感染，导致数千手足口病和疱疹性咽峡炎的患者，其中一些人死亡。） METHODS: We assessed the epidemiologic aspects of this outbreak. Cases of hand-foot-and-mouth disease or herpangina in ambulatory patients were reported to the Taiwan Department of Health by a mean of 818 sentinel physicians.（方法：我们评估了这次暴发的流行病学影响。急诊病人中手足口病或疱疹性咽峡炎的病例来自台湾卫生部，通过调查818名值班医生得到。） Severe cases in hospitalized patients were reported by 40 medical centers and regional hospitals. （住院患者中的重症病例来自40家医疗中心和地区医院。）Viruses were isolated by 10 hospital laboratories and the department of health. （病毒株分离自10家医院实验室和卫生部的实验室。）RESULTS: The sentinel physicians reported 129,106 cases of hand-foot-and-mouth disease or herpangina in two waves of the epidemic, which probably represents less than 10 percent of the estimated total number of cases.（结果：值班医生报告在两波大流行中共有129106个手足口病或疱疹性咽峡炎病例，可能比估计的总发病数少10%。） There were 405 patients with severe disease, most of whom were five years old or younger; severe disease was seen in all regions of the island. （405例重症患者，大部分为五岁或更小的幼儿，重症患者在全岛范围都有报告。）Complications included encephalitis, aseptic meningitis, pulmonary edema or hemorrhage, acute flaccid paralysis, and myocarditis.（并发症包括脑炎、急性脑膜炎，肺水肿或肺出血，急性驰缓性麻痹和心肌炎。） Seventy-eight patients died, 71 of whom (91 percent) were five years of age or younger. （78人死亡，其中71人占91%为五岁以下幼童。）Of the patients who died, 65 (83 percent) had pulmonary edema or pulmonary hemorrhage.（65人占83%的死亡原因为肺水肿或肺出血。） Among patients from whom a virus was isolated, enterovirus 71 was present in 48.7 percent of outpatients with uncomplicated hand-foot-and-mouth disease or herpangina, 75 percent of hospitalized patients who survived, and 92 percent of patients who died. （48.7%的诊断为单纯手足口病的门诊病人，75%的存活住院患者和92%的死亡患者体内分离出肠病毒EV71病毒株。）CONCLUSIONS: Although several enteroviruses were circulating in Taiwan during the 1998 epidemic, enterovirus 71 infection was associated with most of the serious clinical manifestations and with nearly all the deaths. （结论：尽管在这次1998年台湾暴发中有几种肠病毒流行，但肠病毒EV71感染却与绝大多数重症感染相关，几乎所有死亡病例均检出EV71.）Most of those who died were young, and the majority died of pulmonary edema and pulmonary hemorrhage.(大部分死者为幼童，绝大部分死于肺水肿和肺出血。)

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