科学家发现能引起骨骼感染的细菌
Scientists discover bacteria that can cause bone infections
科学家发现能引起骨骼感染的细菌
Scientists have discovered that a bone infection is caused by a newly described species of bacteria that is related to the tuberculosis pathogen. The discovery may help improve the diagnosis and treatment of similar infections, according to an article published in the October issue of the International Journal of Systematic and Evolutionary Microbiology.
发表在国际系统与进化微生物学杂志10月号上的一篇文章指出，科学家发现某种骨骼感染是由一种新近描述的细菌种类引起，后者与结核杆菌具有亲缘关系。这一发现可能对改进类似感染的诊断与治疗具有帮助意义。
Some rare genetic diseases can make patients susceptible to infections with Mycobacterium species, the bacteria that amongst other diseases, cause tuberculosis and leprosy. These patients often suffer from recurring mycobacterial infections throughout their whole lives. Because of this, researchers are trying to identify unusual species that cause disease in order to improve treatment strategies.
某些罕见的遗传性疾病会造成患者对分支杆菌属极其易感，这一类细菌中的一些成员就是结核病和麻风病的病原体。这些患者常常在一生中都受到反复发作的感染的折磨。正因为如此，研究者们试图识别出那些导致疾病的不常见的细菌种类，从而改进治疗策略。
"We isolated an unknown species of bacteria from a 7 year old child who has a genetic immune defect," said Dr Didi Bang from Statens Serum Institut in Copenhagen, Denmark. "The infection had caused bone lesions and this is where we found the newly described bacteria."
“我们从一名7岁的遗传免疫缺陷患者体内分离出一种未知的细菌，”丹麦哥本哈根Statens血清研究所的Dr Didi Bang说，“感染引起了骨损害，在病灶中我们找到了这种新近描述的细菌。”
Mycobacterial infections can be very difficult to treat. The bacteria have unique cell walls that protect them from several antibiotics. As well as being resistant to treatment, they can also survive attack with acids, alkalis and detergents. Most mycobacterial infections can be treated with antibiotics such as clarithromycin and rifamycins, but some species are becoming resistant to these antibiotics, so new drugs for treatments must be developed.
分支杆菌感染往往难以治疗。它们具有特殊的细胞壁，保护它们免受多种抗生素的杀灭。不仅对药物抵抗，它们在酸、碱和去污剂中同样能很好存活。大多数分支杆菌感染能用诸如克拉霉素和利福霉素这样的抗生素治疗，但一些种类对这些抗生素正在变得耐药，所以新药物的研制势在必行。
"Initial tests suggested we had found a Mycobacterium. By sequencing some of the bacterium's genes we showed that we had discovered an undescribed species," said Dr Bang. "We called the bacterium Mycobacterium arosiense. The name comes from Arosia, the Latin name of the city of Aarhus in Denmark, which is where the bacterium was first found. We showed the position of the new bacterium on the Mycobacterium family tree by sequencing genes and comparing them to related bacteria."
“最初的检验提示我们发现的是分支杆菌属的细菌。对其一部分基因进行测序则告诉我们，这是一种从未被描述过的种类，”Dr Bang说，“我们把它命名为分支杆菌属arosiense种，这个词来源于Arosia，即丹麦城市Aarhus的拉丁文名称，在那里我们发现了这种细菌。通过基因测序，我们已经把这种新菌种在分支杆菌属的族谱树上的位置标示了出来，并把它同与其有亲缘关系的细菌进行了比较。”
The new pathogen is closely related to Mycobacterium intracellulare and Mycobacterium avium, which cause a lung disease similar to tuberculosis in people, especially those with weak immune systems such as HIV patients that are immunologically suppressed. It is rod-shaped and grows slowly.
这种新菌种与分支杆菌属的胞内分支杆菌和鸟肠球菌的亲缘关系比较接近，后者在人类可引起与结核病相似的肺部感染，特别是在那些因为HIV感染导致免疫缺陷的患者。它具有杆状的外形，生长缓慢。
"Mycobacterium arosiense can be killed by several antibiotics in the lab, including clarithromycin and rifamycins. However, resistance to fluoroquinolones and isoniazid was observed," said Dr Bang. "Little knowledge is available on performing resistance tests on mycobacteria other than tuberculosis."
“分支杆菌属arosiense种在实验室里能被许多抗生素杀死，包括克拉霉素和利福霉素。不过，我们观察到它对氟喹诺酮类和异烟肼是耐药的，”Dr Bang指出，“我们在测试除结核杆菌以外的分支杆菌属的耐药性方面知识不多。”
"We hope that this discovery will help doctors to diagnose similar diseases in the future and that further investigation may improve the treatment of people with similar infections."
“我们希望这个发现能在未来帮助医生诊断类似的疾病，而且，进一步的研究能改进对类似感染患者的治疗手段。”
Source : Society for General Microbiology
来源：普通微生物学学会
编译：
科学家发现能引起骨骼感染的细菌
发表在国际系统与进化微生物学杂志10月号上的一篇文章指出，科学家发现某种骨骼感染是由一种新近描述的细菌种类引起，后者与结核杆菌具有亲缘关系。这一发现可能对改进类似感染的诊断与治疗具有帮助意义。
某些罕见的遗传性疾病会造成患者对分支杆菌属极其易感，这一类细菌中的一些成员就是结核病和麻风病的病原体。这些患者常常在一生中都受到反复发作的感染的折磨。正因为如此，研究者们试图识别出那些导致疾病的不常见的细菌种类，从而改进治疗策略。
“我们从一名7岁的遗传免疫缺陷患者体内分离出一种未知的细菌，”丹麦哥本哈根Statens血清研究所的Dr Didi Bang说，“感染引起了骨损害，在病灶中我们找到了这种新近描述的细菌。”
分支杆菌感染往往难以治疗。它们具有特殊的细胞壁，保护它们免受多种抗生素的杀灭。不仅对药物抵抗，它们在酸、碱和去污剂中同样能很好存活。大多数分支杆菌感染能用诸如克拉霉素和利福霉素这样的抗生素治疗，但一些种类对这些抗生素正在变得耐药，所以新药物的研制势在必行。
“最初的检验提示我们发现的是分支杆菌属的细菌。对其一部分基因进行测序则告诉我们，这是一种从未被描述过的种类，”Dr Bang说，“我们把它命名为分支杆菌属arosiense种，这个词来源于Arosia，即丹麦城市Aarhus的拉丁文名称，在那里我们发现了这种细菌。通过基因测序，我们已经把这种新菌种在分支杆菌属的族谱树上的位置标示了出来，并把它同与其有亲缘关系的细菌进行了比较。”
这种新菌种与分支杆菌属的胞内分支杆菌和鸟肠球菌的亲缘关系比较接近，后者在人类可引起与结核病相似的肺部感染，特别是在那些因为HIV感染导致免疫缺陷的患者。它具有杆状的外形，生长缓慢。
“分支杆菌属arosiense种在实验室里能被许多抗生素杀死，包括克拉霉素和利福霉素。不过，我们观察到它对氟喹诺酮类和异烟肼是耐药的，”Dr Bang指出，“我们在测试除结核杆菌以外的分支杆菌属的耐药性方面知识不多。”
“我们希望这个发现能在未来帮助医生诊断类似的疾病，而且，进一步的研究能改进对类似感染患者的治疗手段。”
来源：普通微生物学学会
科学家发现能引起骨骼感染的细菌
Scientists have discovered that a bone infection is caused by a newly described species of bacteria that is related to the tuberculosis pathogen. The discovery may help improve the diagnosis and treatment of similar infections, according to an article published in the October issue of the International Journal of Systematic and Evolutionary Microbiology.
发表在国际系统与进化微生物学杂志10月号上的一篇文章指出，科学家发现某种骨骼感染是由一种新近描述的细菌种类引起，后者与结核杆菌具有亲缘关系。这一发现可能对改进类似感染的诊断与治疗具有帮助意义。
Some rare genetic diseases can make patients susceptible to infections with Mycobacterium species, the bacteria that amongst other diseases, cause tuberculosis and leprosy. These patients often suffer from recurring mycobacterial infections throughout their whole lives. Because of this, researchers are trying to identify unusual species that cause disease in order to improve treatment strategies.
某些罕见的遗传性疾病会造成患者对分支杆菌属极其易感，这一类细菌中的一些成员就是结核病和麻风病的病原体。这些患者常常在一生中都受到反复发作的感染的折磨。正因为如此，研究者们试图识别出那些导致疾病的不常见的细菌种类，从而改进治疗策略。
"We isolated an unknown species of bacteria from a 7 year old child who has a genetic immune defect," said Dr Didi Bang from Statens Serum Institut in Copenhagen, Denmark. "The infection had caused bone lesions and this is where we found the newly described bacteria."
“我们从一名7岁的遗传免疫缺陷患者体内分离出一种未知的细菌，”丹麦哥本哈根Statens血清研究所的Dr Didi Bang说，“感染引起了骨损害，在病灶中我们找到了这种新近描述的细菌。”
Mycobacterial infections can be very difficult to treat. The bacteria have unique cell walls that protect them from several antibiotics. As well as being resistant to treatment, they can also survive attack with acids, alkalis and detergents. Most mycobacterial infections can be treated with antibiotics such as clarithromycin and rifamycins, but some species are becoming resistant to these antibiotics, so new drugs for treatments must be developed.
分支杆菌感染往往难以治疗。它们具有特殊的细胞壁，保护它们免受多种抗生素的杀灭。不仅对药物抵抗，它们在酸、碱和去污剂中同样能很好存活。大多数分支杆菌感染能用诸如克拉霉素和利福霉素这样的抗生素治疗，但一些种类对这些抗生素正在变得耐药，所以新药物的研制势在必行。
"Initial tests suggested we had found a Mycobacterium. By sequencing some of the bacterium's genes we showed that we had discovered an undescribed species," said Dr Bang. "We called the bacterium Mycobacterium arosiense. The name comes from Arosia, the Latin name of the city of Aarhus in Denmark, which is where the bacterium was first found. We showed the position of the new bacterium on the Mycobacterium family tree by sequencing genes and comparing them to related bacteria."
“最初的检验提示我们发现的是分支杆菌属的细菌。对其一部分基因进行测序则告诉我们，这是一种从未被描述过的种类，”Dr Bang说，“我们把它命名为分支杆菌属arosiense种，这个词来源于Arosia，即丹麦城市Aarhus的拉丁文名称，在那里我们发现了这种细菌。通过基因测序，我们已经把这种新菌种在分支杆菌属的族谱树上的位置标示了出来，并把它同与其有亲缘关系的细菌进行了比较。”
The new pathogen is closely related to Mycobacterium intracellulare and Mycobacterium avium, which cause a lung disease similar to tuberculosis in people, especially those with weak immune systems such as HIV patients that are immunologically suppressed. It is rod-shaped and grows slowly.
这种新菌种与分支杆菌属的胞内分支杆菌和鸟肠球菌的亲缘关系比较接近，后者在人类可引起与结核病相似的肺部感染，特别是在那些因为HIV感染导致免疫缺陷的患者。它具有杆状的外形，生长缓慢。
"Mycobacterium arosiense can be killed by several antibiotics in the lab, including clarithromycin and rifamycins. However, resistance to fluoroquinolones and isoniazid was observed," said Dr Bang. "Little knowledge is available on performing resistance tests on mycobacteria other than tuberculosis."
“分支杆菌属arosiense种在实验室里能被许多抗生素杀死，包括克拉霉素和利福霉素。不过，我们观察到它对氟喹诺酮类和异烟肼是耐药的，”Dr Bang指出，“我们在测试除结核杆菌以外的分支杆菌属的耐药性方面知识不多。”
"We hope that this discovery will help doctors to diagnose similar diseases in the future and that further investigation may improve the treatment of people with similar infections."
“我们希望这个发现能在未来帮助医生诊断类似的疾病，而且，进一步的研究能改进对类似感染患者的治疗手段。”
Source : Society for General Microbiology
来源：普通微生物学学会
编译：
科学家发现能引起骨骼感染的细菌
发表在国际系统与进化微生物学杂志10月号上的一篇文章指出，科学家发现某种骨骼感染是由一种新近描述的细菌种类引起，后者与结核杆菌具有亲缘关系。这一发现可能对改进类似感染的诊断与治疗具有帮助意义。
某些罕见的遗传性疾病会造成患者对分支杆菌属极其易感，这一类细菌中的一些成员就是结核病和麻风病的病原体。这些患者常常在一生中都受到反复发作的感染的折磨。正因为如此，研究者们试图识别出那些导致疾病的不常见的细菌种类，从而改进治疗策略。
“我们从一名7岁的遗传免疫缺陷患者体内分离出一种未知的细菌，”丹麦哥本哈根Statens血清研究所的Dr Didi Bang说，“感染引起了骨损害，在病灶中我们找到了这种新近描述的细菌。”
分支杆菌感染往往难以治疗。它们具有特殊的细胞壁，保护它们免受多种抗生素的杀灭。不仅对药物抵抗，它们在酸、碱和去污剂中同样能很好存活。大多数分支杆菌感染能用诸如克拉霉素和利福霉素这样的抗生素治疗，但一些种类对这些抗生素正在变得耐药，所以新药物的研制势在必行。
“最初的检验提示我们发现的是分支杆菌属的细菌。对其一部分基因进行测序则告诉我们，这是一种从未被描述过的种类，”Dr Bang说，“我们把它命名为分支杆菌属arosiense种，这个词来源于Arosia，即丹麦城市Aarhus的拉丁文名称，在那里我们发现了这种细菌。通过基因测序，我们已经把这种新菌种在分支杆菌属的族谱树上的位置标示了出来，并把它同与其有亲缘关系的细菌进行了比较。”
这种新菌种与分支杆菌属的胞内分支杆菌和鸟肠球菌的亲缘关系比较接近，后者在人类可引起与结核病相似的肺部感染，特别是在那些因为HIV感染导致免疫缺陷的患者。它具有杆状的外形，生长缓慢。
“分支杆菌属arosiense种在实验室里能被许多抗生素杀死，包括克拉霉素和利福霉素。不过，我们观察到它对氟喹诺酮类和异烟肼是耐药的，”Dr Bang指出，“我们在测试除结核杆菌以外的分支杆菌属的耐药性方面知识不多。”
“我们希望这个发现能在未来帮助医生诊断类似的疾病，而且，进一步的研究能改进对类似感染患者的治疗手段。”
来源：普通微生物学学会
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